Python Job: Internship - Master student in “Tumor-associated i

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare.
We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The position

Pharmaceutical Sciences (PS) is a global function within Roche Pharma Research and Early Development (pRED). As a team member in the Predictive Modeling and Data Analytics (PMDA) chapter of PS, you will work in close collaboration with scientists in pRED, using state-of-the-art bioinformatics and biostatistics tools and methods. The focus of the position is on improving our understanding of the relation between different inflammatory pathways, T cell phenotypes and cancer immunotherapy treatment (CIT). Towards this, alongside PMDA members, you will closely collaborate with the Early Development Oncology (EDO) team, specifically with biomarker experts focusing on cancer immunotherapy projects. By studying what type of inflammation is needed to trigger/maintain an effective anti-tumor immune response, you will help us contribute to our prime responsibility of developing safe and efficacious drugs.

We are looking for individuals who:

• Are creative problem solvers, quick learners and comfortable experimenting with new approaches

• Demonstrate high productivity and enjoy dealing with ambiguity and applying novel methodologies

• Possess entrepreneurship, passion and curiosity for understanding and interrogating complex data.

In this position you will:

• Establish a collection of inflammatory pathways of interest through performing literature review

• Perform bioinformatics analyses to dissect which of our treatments of interest induce which inflammatory pathways using internal single-cell and bulk RNA-seq data in preclinical models and patient data

• Explore the relation between the inflammatory pathways, immune cell phenotypes and cancer immunotherapy treatment using internal clinical data collections and publicly available single-cell RNA-seq datasets

• Share the gathered knowledge and data with the broader community

Qualifications Required:

You are currently enrolled in a Master's or PhD programme and have a Bachelor or Master’s degree in bioinformatics or a related discipline (e.g. computer science, biomedicine, biological sciences, biostatistics). You have a good understanding of molecular biology and genomics.

You have experience and expertise in the following:

• Proficiency in programming (Python and/or R) and sequencing data analysis

• Strong analytical skills and proficiency in applying statistical methods

• Prior knowledge of immunology and cancer immunotherapy is a plus

• Highly effective verbal and written communication and presentation skills in English

• Highly collaborative mindset that enjoys working in multidisciplinary and international teams

You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.

When does it start?

The preferred start date of this internship is Q2 2023, or on availability. In case of specific preferences, please indicate your preferred starting date in your motivation letter. All applications need to include a CV and a motivation letter.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Due to regulations non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.